In 2000, Wayne was named co-Pac-10 Pitcher of the Year, with a 15–4 record and a 3.21 ERA, with Stanford reaching the finals of the College World Series.

[4] In 2001, he ended his first full minor league season at Double-A for the Harrisburg Senators, where he went 9–2 with a 2.62 ERA in 14 starts for a losing team (.465 winning percentage).

[5] In July 2002, Wayne was traded by the Expos with Graeme Lloyd, Mike Mordecai, Donald Levinski, and Carl Pavano to the Florida Marlins for Cliff Floyd, Wilton Guerrero, Claudio Vargas, and cash.

[7] In April 2005, Wayne signed as a free agent with the Los Angeles Dodgers; he made four appearances for their Triple-A affiliate, the Las Vegas 51s, recording a 14.40 ERA.

In 10 appearances, Wayne pitched 18 innings, gave up 6 earned runs, walked 17, struck out 9, and had a 3.00 ERA with a 1–2 record.

He has continued in this field and is now a Managing Partner and Chief Operating Officer of SMART Lab, located in Palm Beach Gardens, Florida.

In 2018, Wayne received a two-year federal prison sentence at a minimum-security federal prison camp at Maxwell Air Force Base in Montgomery, Alabama, for an "insurance scam" involving Hawkeye, who received a 40-month sentence: "The brothers owned a testing lab.