Justinianopolis in Armenia

It was one of several ancient sites renamed in late Antiquity after Byzantine emperor Justinian I.

Acilisene was a province situated between the Euphrates and Antitaurus, where Mithridates VI of Pontus, pursued by Pompey, sought refuge.

[6] The diocese survived the Islamic invasion and was still extant when Marco Polo visited the town.

After the 13th century there is no mention of diocesan bishops of Acilisene and the see no longer appears in Notitiae Episcopatuum.

[7] No longer a residential bishopric, Acilisene is today listed by the Roman Catholic Church as a titular see.