He did not seek his father’s permission to be a priest but, because of his persistence, was allowed to enter the seminary on 30 September 1935.
After ordination, he was first appointed to serve at Kidul Loji Church, Yogyakarta, for 35 days.
After a few months in Surakarta, he was ordered to study missiology at Pontifical Gregorian University, Rome.
He was received by President Sukarno at Merdeka Palace immediately after being ordained archbishop of Semarang in 1964.
Nome di Gesù e Maria in Via Lata by Pope Paul VI on 26 June 1967, as a member of the College of Cardinals.
He was appointed cardinal together with Karol Wojtyla from Poland, who later became Pope John Paul II.
When Pope Paul VI visited Manila in 1970, he lobbied widely, together with Bishop Labayen from the Philippines and Cardinal Stephen Kim Sou-hwan from South Korea, for the establishment of Federation of Asian Bishops' Conferences.
Darmojuwono as a member of the Standing Committee of that conference, and so attended FABC meetings outside the country.
He was buried at Kerkhoof Muntilan cemetery, beside other prominent Catholics like Van Lith, SJ, and RD.