K-1 World Grand Prix 2008 in Seoul Final 16 was a martial arts event held by the K-1 on Saturday September 27, 2008 at the Olympic Gymnastics Arena in Seoul, Korea.

The winners qualified for the K-1 World GP 2008 Final held on December 6, 2008, at Yokohama Arena, Japan.

The K-1 World GP 2008 Final 16 attracted a crowd of 15,769 to the Seoul Olympic Complex and was broadcast live across South Korea by CJ Media and in Japan on the Fuji TV Network.

* Reserve Fight winner Brian Douwes replaced Freddy Kemayo in the Semi Finals as Freddy Kemayo was unable to continue due to injury * Reserve Fight winner Vaughn Anderson replaced Makoto Uehara in the Semi Finals as Makoto Uehara was unable to continue due to injury * Reserve Fight winner Randy Kim replaced Mighty Mo in the Semi Finals as Mighty Mo could not continue due to injury Paul Slowinski earned a wild-card spot on the card through a fan poll on the K-1 website.

Ray Sefo of New Zealand and Chalid "Die Faust" Arrab from Germany were also voted into the tournament.