[5][6][7] Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids.

It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis[7] Besides its role in translation, Lysyl-tRNA synthetase is involved in a signaling pathway leading to gene activation.

Such physiological stimulation includes immunological activation of mast cells, so this pathway maybe relevant to the allergic response.

KARS (gene) has been shown to interact with Multisynthetase complex auxiliary component p38.

[11][12] Physiological trigger such as immunological activation results in the phosphorylation of LysRS on its serine residues.