Bayer withdrew its sponsorship of the football team in 1995 at which time the club took on the name Krefelder Fußball-Club Uerdingen 05.

By the early 1960s they had advanced as far as the Amateurliga Niederrhein (III) where they would play until 1971 when they stepped up into the Regionalliga West (II).

Uerdingen also captured the DFB-Pokal (German Cup) in 1985 with a 2–1 victory over Bundesliga champions Bayern Munich in Berlin's Olympiastadion.

After the 1995 season Bayer withdrew its sponsorship of the football team which has suffered chronic financial difficulties ever since.

The club's persistent financial problems led the DFB to deny them a license for play in the Regionalliga Nord (III) in 2003 despite a mid-table finish and they were relegated to the Oberliga Nordrhein (IV).

Veteran manager and Fortuna Düsseldorf legend Aleksandar Ristić was put in charge of the team as German football was reorganised with the introduction the new 3.

It won a league championship at this level in 2013 and was promoted to the Regionalliga West but relegated back to the Oberliga again in 2015.

In January 2021, outgoing president Mikhail Ponomarev and his deputy Nicolas Weinhardt announced their departure from the club and shortly after, stated that due to financial losses caused mainly by the impact of the COVID-19 pandemic on association football and an unclear situation regarding the stadium in Krefeld, it had filed for insolvency.

[8] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.