115653245615ENSG00000276086ENSG00000283875ENSG00000274480ENSG00000277392ENSG00000274786ENSG00000274724ENSG00000276930ENSG00000276572ENSG00000284371ENSG00000276084ENSG00000284104ENSG00000278729ENSG00000277028ENSG00000275062ENSG00000274763ENSG00000276433ENSG00000274639ENSG00000283966ENSG00000284127ENSG00000277552ENSG00000278490ENSG00000276806ENSG00000242019ENSG00000276328ENSG00000276875ENSG00000274556ENSG00000283915ENSG00000284086ENSG00000278723ENSG00000284480ENSG00000273502ENSG00000274254ENSG00000275172ENSG00000275513ENSG00000277620ENSG00000274696ENSG00000277596ENSMUSG00000057439Q8N743Q673W2NM_153443NM_177748NP_703144NP_808416Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene.

The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC).

KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.

The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

This gene is one of the "framework" loci that is present on all haplotypes.