[5][6] NEPH1 is a member of the NEPH protein family, which includes NEPH2 (KIRREL3, MIM 607761) and NEPH3 (KIRREL2, MIM 607762).

The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766).

NEPH1 is expressed in filtration slits of kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration of blood (Sellin et al., 2003).

[supplied by OMIM][6] KIRREL has been shown to interact with Nephrin[7][8] and Tight junction protein 1.

This article on a gene on human chromosome 1 is a stub.