KOTI covers areas of southwest and south-central Oregon that receive a marginal to non-existent over-the-air signal from KOBI, although there is significant overlap between the two stations' contours otherwise.

Smullin soon realized that KBES' signal was not strong enough to cover all of southern Oregon, which the FCC had ruled was part of the Medford market, so he bought the license for channel 2 in Klamath Falls, and KOTI debuted on August 12, 1956.

[3] When channel 10 was allocated to Medford, Smullin helped the owners of KMED get the license, as well as space on his transmitter on Blackwell Hill.

[6] During the 1980s, KOBI broadcast a popular interactive game show called Jackpot Bingo, hosted by Tom Carnes.

Carnes was replaced by Sally Holliday in 1987 and the show was renamed $10,000 Jackpot Bingo as the prize money doubled.

Each school brings in a team of five students, four participating and one alternate, who answer a series of questions from the host, NBC 5 chief meteorologist Jeff Heaton, on topics such as history, math, literature, current events and a variety of other categories.

NBC 5's newly hired general manager Bob Wise brought the identically formatted program to southern Oregon in 2005.

In 2005, KOBI started a special program called the Southern Oregon Meth Project to educate viewers and concerned citizens about the dangers of methamphetamine and what can be done to prevent it.

The project was headed up by KOBI's lead news anchor Christina Anderson, where she remained until her departure for KOVR in Sacramento in 2010.

KOTI previously produced its own newscasts (separate from KOBI) focusing on the eastern portion of the Medford–Klamath Falls market.

[8] The stations' signals are multiplexed: KOBI shut down its analog signal, over VHF channel 5, on February 17, 2009, the original target date on which full-power television stations in the United States were to transition from analog to digital broadcasts under federal mandate (which was later pushed back to June 12, 2009).