[10] Ellen Terry opened the theatre, then the most celebrated actress in England, who had lived in nearby Stanhope Street as a child.

[11] The venue was particularly popular with new wave and punk bands, hosting concerts by groups including The Boomtown Rats, The Clash, and The Jam .

During this time the legendary weekly house/acid house event, "Clockwork Orange" was held on a Saturday with Andy Manston and Danny Gould running until 2001, "Frantic" (hard house/trance) and the iconic house/trance event "Peach" with Graham Gold, Pele, Darren Pearce and Dave Lambert running until the Camden Palace closed in 2004.

[20] The Daily Telegraph described the modern interior amenities and the building's historic facade as "lend[ing] a sense of grandeur to any gig".

[27][28] Since the 2004 restoration, Koko's commitment to sustainability has been recognised with an award for Environmental Excellence in Camden Organisations (EECO), for Innovation in Waste Management and Recycling.

"[30] The key points in Koko's recycling and waste management strategy include: On 19 March 1964, The Rolling Stones performed at the venue.

The cult London electronic band You You You, consisting of Karen O'Connor, Laurence Malice, and Iain Williams,[32] performed their debut concert at the Camden Palace on January 13, 1987.

Their appearance at the Camden Palace attracted over 1,000 people on what the Met Office recorded as probably being England's coldest night of the 20th Century.

[18] The next year, in 2006, Elton John hosted a benefit party at Koko for his AIDS Charity Bash, attended by Natalie Imbruglia, Elle Macpherson, Jade Jagger, and Kevin Spacey.

[15] Later in 2007, The Disney Channel used Koko to host Hannah Montana's Live in London, an exclusive one-off event broadcast globally for her fans.

[15][39][40] In 2008, Siouxsie Sioux recorded a live DVD at Koko called Finale: The Last Mantaray & More Show, which was released the following year.

In 2009, Koko hosted the iTunes festival, which extended over 30 nights and featured guests including N.E.R.D, Paul Weller, James Blunt, Calvin Harris and Dizzee Rascal and over 45,000 people.

[41] In 2010, Koko also hosted fundraiser for the Institute of Contemporary Arts, featuring a performance Lily Allen and Bryan Ferry and attended by Vivienne Westwood, Damien Hirst, and Tracey Emin.

[42] Since its restoration, the club has attracted well known musicians and DJs including: The Damned, Terrorvision, Al Murray, Irfan Latif, Don Broco, Red Hot Chili Peppers, Madonna, Christina Aguilera, Coldplay, Tori Kelly, Katy B, My Chemical Romance, Emma Marrone, Oasis, Bruno Mars, Thom Yorke, Amy Winehouse, La Roux, James Marriott, Skrillex, Lady Gaga, The Killers, Kanye West, Katy Perry, Tokio Hotel, Lily Allen, Poppy, Demi Lovato, Usher, Noel Gallagher, Wargasm, Swedish House Mafia, JoJo, Azealia Banks, Rolling Blackouts Coastal Fever, Masters at Work and many others.