In 1925, when the World Advertising Convention was to be held in Houston featuring U.S. Commerce Secretary Herbert Hoover, Daniel again talked to Sterling Sr. about the radio station idea.

Guests on the opening broadcast included William P. Hobby, Texas poet laureate Judd Mortimer Lewis, and the First Garrison Band of Mexico.

[7]: 3 [8] Tex Ritter had a Saturday show on KPRC in the late 1920s singing original country ballads.

[10][11] Connecting the four stations by telephone line, TQN enabled them to make simultaneous broadcasts of the same program.

[10] KPRC moved to its current frequency of 950 kHz on May 22, 1941, under the terms of the North American Regional Broadcasting Agreement (NARBA).

[21] In 1962, KPRC broadcast the inaugural season of the Houston Colt .45s, a new Major League Baseball team.

[22] When the Colt .45s became the Houston Astros in 1965, KPRC continued broadcasting the games, with Gene Elston and Loel Passe hired as announcers.

[24] The strong ratings continued into 1966, when KPRC began adding comedy shows and jazz music.

KPRC showed improvement in the spring 1977 Arbitron ratings from a year ago, this time averaging 17,200 listeners per week and ranking eighth in Houston/Galveston.

[38][39] With that acquisition, former KHOU sports director Dan Patrick became general manager and part-owner of both KPRC and sister station KSEV.

Following the sale closing, in an effort to make the two stations more competitive against KTRH, Patrick announced changes to the KPRC and KSEV schedules to focus on conservative talk radio effective April 5, 1993.

Branded as "Supertalk Radio", both stations would simulcast The Rush Limbaugh Show; KPRC also added commentary segments by Paul Harvey and Jim Hightower and a sports talk show co-hosted by Houston Chronicle columnist Ed Fowler and play-by-play announcer John O'Reilly, Sports Page.

[42][43] Then in March 1994, Patrick hired former Houston mayor Kathy Whitmire, a Democrat, to host a nightly show.

[48][49] Among the Astros' stated reasons for the change of affiliation were a perceived stronger signal from KILT and the sports format allowing for more promotion of the team, in contrast to KPRC moving some games to KSEV when there were conflicts with regularly scheduled talk shows like Rush Limbaugh.

[48] However, Patrick disputed the Astros' claim about KILT having a stronger signal due to both stations having 5 kW of power.

[51] Beginning around December 1998, KPRC hired former Apollo 7 astronaut Walter Cunningham to host a nightly 8 p.m. show, Liftoff to Logic.

[52][53] On August 29, 2000, Patrick resigned from KPRC after seven years as general manager and talk show host.

[64] On July 28, 2014, KPRC signed a contract to broadcast University of Houston football and men's basketball.

At night, to avoid interference to other stations on 950 AM, it reduces power to 4,300 watts and it uses a directional antenna with a four-tower array.