[8] The protein is a type I transmembrane receptor of ligands Dickkopf1,[9] Dickkopf2, Dickkopf3, Dickkopf4, EpCAM[10] and Rspondin1.

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling.

Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

[8] This proapototic activity is conditional and depends on the absence of ligand Dickkopf1.

[8] These observations led to the classification of this protein as a Dependence Receptor.