The RC16 made its debut as a wildcard entry at the 2016 Valencian Community motorcycle Grand Prix with test rider Mika Kallio.

[1] For KTM's return to MotoGP in 2017, their new factory team signed 2009 125cc runner-up, Bradley Smith and the 2013 Moto2 Champion, Pol Espargaró from Monster Yamaha Tech3.

[5] In 2020 Brad Binder achieved KTM's first win as a constructor in the premier MotoGP class at the Czech Grand Prix.

[6] Miguel Oliveira took KTM's second race win, and first for satellite team Tech3, just two rounds later at the Styrian Grand Prix.

(2016-2019: tubular steel trellis) (2016-2019: aluminium construction) These results are accurate up to the 2023 Valencian Community motorcycle Grand Prix.