Prior to moving up into Grand Prix level, Binder contested three seasons of the Red Bull MotoGP Rookies Cup, with a best finish of fifth overall in the championship standings.

Binder started his Grand Prix career in the 125cc class riding an Aprilia for RW Racing GP in the 2011 season with his bike number as 14.

In the 2016 season, he built on this success with 7 wins and 14 podiums en route to his first world championship, with a 142 point margin over 2nd place.

Binder made his MotoGP debut with Red Bull KTM Factory Racing team in the 2020 season.

Binder scored a surprise home track victory for KTM at the Austrian MotoGP Grand Prix when, with 5 laps remaining and rain beginning to fall, he decided to take the chance of finishing the race on slicks while most other leading riders chose to pit and swap to motorcycles fitted with wet tires.

The gamble paid off and despite extremely slick conditions and mostly ineffective brakes due to the wet and cold track surface, he was able to withstand a late charge by Ducati rider Francesco Bagnaia and win the race.

Binder stayed with Red Bull KTM Factory Racing team for a third consecutive season for the 2022 World Championship.

[6] He attained his first ever top 3 qualifying result in MotoGP at the 2022 Japanese Grand Prix, which he followed up with his second podium finish of the season, in 2nd position.

Binder signed a contract with Red Bull KTM Factory Racing in June 2021, to remain with the team for the 2023 World Championship and 2024.