The station signed on in 1961, as KLUB-FM, airing a music format partially simulcast with KLUB-AM.

[4] This format included a mix of soft rock, pop hits, and ballads from the 1970s, 80s, and 90s.

This format focused exclusively on music from the 1980s, featuring a wide array of genres.

In 2001, KISN joined at least four other Clear Channel stations in the U.S. in airing "Martha Quinn's Rewind," a program hosted by former MTV VJ Martha Quinn.

This led to the station beginning to play the most popular and current songs across various genres, including pop, hip-hop, dance, and R&B.