It starts from Dashte Barchi in Kabul and passes through Maidan Shar, Saydabad, Ghazni, and Qalat until it reaches Aino Mina in Kandahar.

The Kabul–Kandahar Highway is said to have been designed and asphalted in the 1960s by Afghan and American engineers under contracts with the United States International Cooperation Administration.

In the 1980s, in addition to trucks and private vehicles, military convoys of the Soviet Union were often seen passing back and forth between Kabul and Kandahar.

The rebuilding project was overseen by the Louis Berger Group, with assistance in planning and design by Turkish and Indian engineers.

[14] The Dashte Barchi bus terminus provides transport services to the provinces of Maidan Wardak, Bamyan, Ghazni, Daikundi and Ghor.

[15] Another such terminal is in Aino Mina in Kandahar,[16] and yet another on the western end of that city which provides bus services to Lashkar Gah, Zaranj, Farah and Herat.

On May 8, 2016, a major vehicular crash killed at least 73 and injured over 50 people along the Kabul-Kandahar Highway in Moqor District of Ghazni Province.

[20] On December 18, 2024, a total of 50 people are killed and 76 others are injured in two separate crashes along the highway in Ghazni Province, including a collision between a passenger bus and an oil tanker.