In his senior season in 2012, Nacua's athletic prowess led his team to an 11–2 record.

He made the 2015 Phil Steele's Postseason All-Independent First Team and was later named the 2016 College Sports Madness Preseason Defensive Player of the Year.

During the 2016 season, Nacua made 14 career interceptions, breaking a record set by Derwin Gray.

[4][5] Throughout training camp, he competed for a roster spot against Justin Currie and Trey Caldwell.

On September 3, 2017, the Browns waived Nacua and signed him to their practice squad the next day.

[8] Head coach Hue Jackson named Nacua the backup strong safety behind Derrick Kindred to start the regular season.

[9] He made his professional regular season debut in the Browns' season-opening 21–18 loss to the Pittsburgh Steelers.

On December 3, 2017, Nacua made his first career tackle during a 19–10 loss at the Los Angeles Chargers.

Nacua recorded a season-high five solo tackles during the Browns' 27–21 loss to the Green Bay Packers.

[31] Nacua signed with the Michigan Panthers of the United States Football League on May 9, 2023.