During the civil war in 1626, Kaikhosro sided with Giorgi Saakadze against Teimuraz I of Kakheti and followed him into exile in the Ottoman Empire, where they both, after three years of military service, were accused of treason and put to death.
Kaikhosro was a son of Vakhtang I, and a younger brother of Teimuraz I, on whose death at the battle of Marabda against Safavid Iran he succeeded to the fief of Mukhrani in 1625.
Kaikhosro was allied with the warlord Giorgi Saakadze, who helped him to become regent of Kartli during the anti-Iranian rebellion to the chagrin of his rival Zurab, Duke of Aragvi.
Saakadze and Kaikhosro were defeated by Teimuraz and his party at Bazaleti and fled to the Ottoman Empire, where they entered the sultan's military service.
Mukhrani was taken over by Teimuraz I and given in possession to his son David, while children and nephews of Kaikhosro took refuge in western Georgia, in the Kingdom of Imereti.