Kaikhosro was eventually killed by agents of the Ottoman pasha of Akhaltsikhe, who sought regional hegemony in southwestern Caucasus.
On Giorgi's death at the battle of Rokiti against King Alexander IV of Imereti in 1684, Kaikhosro and his brothers fled to the protection of Yusuf, the Ottoman pasha of Akhaltsikhe, while Alexander installed their uncle, Malakia, as the ruler of Guria.
Next year, Kaikhosro returned with troops provided by the pasha, deposed Malakia, and sent him in exile to Akhaltsikhe.
The pasha attempted the reconciliation between the two Gurieli, but Kaikhosro reneged on his promise not to harm Malakia and had his uncle captured and blinded.
This offended the pasha, who sent the bey of Şavşat to Guria with a secret instruction to kill Kaikhosro.