Kuo previously worked as director for international communications for Chinese search engine Baidu.

Before that he was a technology correspondent for Red Herring magazine, and also worked as director of digital strategy, China, for Ogilvy & Mather in Beijing.

[1] In 2010, Kuo started the Sinica[2] show, a current affairs podcast based in Beijing that invites prominent China journalists and China-watchers to participate in uncensored discussions about Chinese political and economic affairs.

Guests and co-hosts have included Gady Epstein, Mary Kay Magistad of Public Radio International, Tania Branigan of The Guardian, Evan Osnos of The New Yorker, Arthur Kroeber of Dragonomics, Jeremy Goldkorn of Danwei and Bill Bishop, founder of CBS MarketWatch.

Kuo and Goldkorn co-hosted the podcast until its sponsor, The China Project (formerly SupChina), announced in November 2023 that it was shutting down operations due to a lack of funding[3][4] He was previously editor-at-large at the digital media company SupChina.