Through a collaboration with audience members who volunteer to control or operate his sculptures, Spelletich's work explores the interface of robots and humans.

At 18, he joined the International Harvester tractor assembly line and as a member of the United Auto Workers Union, he was exposed to mass production and large scale building processes.

[7] Spelletich builds interactive robots and brain machine interfaces using technology currently at the forefront of scientific research for medical, militaristic or consumer applications.

In August 1999, Spin wrote that Spelletich's work was influenced by American punk rock and informed by his "homegrown mechanical expertise" and his "art school exposure to Dadaists and Duchamp.

"[4][18][6][17][19] With Seemen, he constructed "notorious" installations at the Burning Man festival such as the three headed hound Cerebus, an animated fire spewing sculpture made of metal.

The Levitator lifted a volunteer based on a device that measured respiration; another piece used breath analysis to connect a turbine jet engine with an afterburner.