The Kalamazoo Regional Psychiatric Hospital officially opened on 29 August 1859 under the direction of Dr. Edwin Van Deusen, although three women patients had been admitted prior to that time.

In time, two working farms were opened for the care and rehabilitation of patients and were located about 3 miles (4.8 km) to the north and south of the main campus.

Later, a former state tuberculosis sanatorium on Blakeslee was taken over by the hospital and utilized for the treatment and care of elderly patients.

Another landmark on the main campus is the 'gate cottage' situated near Oakland Drive at the entrance to the hospital grounds.

The gatehouse is 'carpenter gothic' in style, featuring board and batten siding, a steep roof and 'gingerbread' ornamentation.