"Cludine" means to block or to enclose, as it is derived from the Latin verb "cludere".
Furthermore, a level of amino acid sequence identity and similarity of ≥43% and ≥50% was found between both A. sulcata Kunitz-type protease inhibitors SA5 II, SA5 III and AsKC1 – AsKC15.
Kalicludine has 48% identity with the amyloid A4 homologue, which is implicated in Alzheimer's disease.
AsKCs have a replacement at position 19 (Ile → Pro), which results in less inhibitory action than BPTI.
[3] Both kalicludines and dendrotoxins increase the release of acetylcholine and enhance the duration of action potentials (AP).