Khalifa Mohammed Tillisi (Arabic: خليفة محمد التليسي;9 May 1930 – 13 January 2010) was a well-known Libyan historian, translator, statesman, and linguist.

Tillisi was born in Tripoli, Italian Tripolitania (present-day Libya), on 9 May 1930, where he first became a teacher then entered politics.

He reached the peak of his political career when he became a minister for information in the cabinets of Mahmud al-Muntasir and Hussein Maziq from 1964 to 1967, Libya's Ambassador to Morocco in 1967 - 1969.

After the political change in Libya in 1969, he had been trialed by the Libyan People's Court, and sentenced to four years in prison.

His past is well remembered among the Libyan people for his renowned contributions to literature and his relaxed kind-hearted nature.