Kalissaye Avifaunal Reserve (KAR) is a small nature reserve in Senegal, located at the mouth of Kalissaye Pond in the middle of the Casamance River.

On the small sandy islands making up the reserve, vegetation consists mainly of Ipomoea pes-caprae, Sporobolus spicatus, and Alternanthera maritima.

The reserve was created in 1978 to protect sea turtle and seabird colonies.

The common dolphin (Delphinus delphis) and the African manatee (Trichechus senegalensis) are also observed in the area.

In 2022, the IPCC Sixth Assessment Report included Kalissaye Avifaunal Reserve in the list of African natural heritage sites which would be threatened by flooding and coastal erosion by the end of the century, but only if climate change followed RCP 8.5, which is the scenario of high and continually increasing greenhouse gas emissions associated with the warming of over 4 °C.,[2] and is no longer considered very likely.