He is currently Member of parliament in Rajya Sabha representing Assam since 14 June 2019 and the National Secretary of Bharatiya Janata Party since 2023.

Kamakhya Prasad Tasa's political career as a leader started at the age of 16, when he became the Secretary of the Assam Tea Tribes Students’ Association, Jorhat Branch in 1991.

In the same year, he was elevated to the position of General Secretary of the central body of the Assam Tea Tribes Students’ Association (ATTSU).

In the arena of national party politics, Kamakhya Prasad Tasa served as the Vice President of BJP Assam Pradesh from 2013 till the year 2017.

Before that he served as the convenor of the Tea Tribes Cell of Bharatiya Janata Party, Assam Pradesh for two consecutive terms from 2005 to 2007 and 2007 to 2010.