He was best known for his portrayal of Antonio Vega on the ABC soap opera, One Life to Live, and as Raul Menendez, the primary antagonist of the 2012 video game, Call of Duty: Black Ops II.

De los Reyes also played Jobe, a demon in the fourth season of Sleepy Hollow, and Ryan Caradine on The Rookie.

De los Reyes starred as a Chicano boxer named Pedro 'Roadman' Quinn, in 1994's acclaimed theatrical production of Blade to the Heat.

In the ring, he's like a short circuit, and his silent scream of triumph is a guaranteed spine-tingler.De los Reyes appeared alongside Patrick Stewart as a "dashing, if thick-tongued" Ferdinand in a 1995 production of William Shakespeare's The Tempest.

In 1995, de los Reyes starred with James Woods, Ed Harris and Sir Anthony Hopkins in Oliver Stone's controversial biopic, Nixon, playing convicted Watergate burglar, Eugenio Martínez.