Much of Dewa Province was controlled by the powerful Mogami clan during the Sengoku period.
Although the Iwaki clan sided with Tokugawa Ieyasu at the Battle of Sekigahara, due to their close familial ties with Satake Yoshinobu, they refused to participate in attack Ieyasu ordered on Uesugi Kagekatsu at Aizuwakamatsu and were consequently dispossessed of their holdings.
In 1616, the Tokugawa shogunate relented, and allowed the clan to have the 10,000 koku Shinano Nakamura Domain.
In 1623, Iwaki Yoshitaka was transferred to the newly created 20,000 koku Kameda Domain, a compact holding consisting of 71 villages in Yuki County where his descendants ruled for 13 generations to the Meiji restoration.
This drew unfavorable attention from the Tokugawa shogunate, and in 1718, when Iwaki Hidetaka died, his successor was selected from a branch of the Date clan.