Maria, Desiree del Valle, Cherry Pie Picache, Jaime Fabregas, Eugene Domingo, Malou de Guzman, Meryll Soriano, Yul Servo, Mark Bautista, and Jomari Yllana in their supporting roles.

The series is based on Pablo S. Gomez fictional character of the same name and a loose adaptation of the 1973 Philippine film of the same title.

Lourdes' "daughter" Veronica is jealous and finds comfort with her Aunt Lucia, who has returned home after beginning a new life with her American husband and stepson Luke.

Maria will get the title role for "Fatima", often referred to as "Imang", but ABS-CBN picked Anne Curtis instead, shortly after she transferred from GMA Network.

This was a reunion between Eula Valdez and Jean Garcia after their successful show Pangako Sa 'Yo, which ran from 2000 up to 2002, when they played rivals Amor and Claudia.

Ten years later, Eula Valdez, Jean Garcia and Jomari Yllana reunited together in The Half Sisters aired on GMA Network.

Like Eula and Jean, this was also the reunion of Jodi and Patrick after the successful of Pangako Sa 'Yo, Tabing Ilog and Darating ang Umaga.

Pablo S. Gomez wrote the script for the series, who also works in another soap opera – Mga Anghel na Walang Langit.