Marudo and Reyes reunited in the series after Star Cinema's Bromance: My Brother's Romance from 2013.

Vivian Velez resigned from the series due to difficulties working with Cristine Reyes.

Tubig at Langis began with Irene (Cristine Reyes), a good and responsible daughter, being made pregnant by Jaime (Victor Silayan).

He decided to leave Irene and their child, Mico (Miguel Vergara), behind, forcing her to raise him on her own.

After five years, Irene has moved on and reconnected with her high school sweetheart, Natoy (Zanjoe Marudo).

One day, Irene and Natoy consulted a doctor because she began showing signs of pregnancy.

Then, the friends of Conching took a group picture but after they have taken a look at it, they saw Jaime hugging Irene whom they mislead as the third party.

Lucy (Dionne Monsanto), Conching's middle child, wants justice for what happened to her mom so she filed cases against Tope and Domeng.

On the second day of court, Natoy testified for Irene saying that he was the only one that Domeng attacked, that he did not touch Conching.

One night, Natoy made a plan on a resort to surprise Irene on her birthday and have a vacation.

Irene set an appointment with a doctor for conceiving a baby and Clara offered to go with her to the hospital.

Natoy on the other hand, had a problem on his business Villadolid seafoods because of his Aunt Mira (Jean Saburit).

Natoy then discovered that Jaime is wanted in Australia for killing his first wife, Nancy (Antoinette Taus) and for borrowing money from his friends without repaying it.

Irene and Lucy made a scene because Clara had the guts to go to Jaime's wake, even though she was the one who killed him.

Irene gave birth while Clara mourned the loss of her child due to a war in prison.

When he tried to escape, he was shot by the police and was killed, which angered Clara who vowed revenge on Natoy and Irene.

Natoy asked Irene to marry him again as a sign of a new start now that there are no more worries about Clara or Nestor.

Ingrid dela Paz was originally part of the lead cast and was supposed to play role of Clara.

[8] Veteran actress Vivian Velez resigned from the Tubig at Langis citing difficulty working with series lead, Cristine Reyes.

"[10] Reyes, during an interview with Boy Abunda, decided not to give further information about the controversy and keep quiet to avoid further problems.

[12] Velez's character was replaced by another veteran actress, Jean Saburit, who played Altamira Peterson, Conching's sister.

[citation needed] The series was supposed to end on September 9, 2016, as ABS-CBN made the announcement on August 22, 2016, that it was down to its last three weeks.

From April 13, 2020, Tubig at Langis was re-aired on ABS-CBN's Primetime Bida evening block, temporarily filling the second part of A Soldier's Heart's timeslot due to the Enhanced community quarantine put in place throughout the entire Luzon because of the COVID-19 pandemic in the Philippines which necessitated a pause in the production of the network's entertainment programs.

[16] The re-runs ended when ABS-CBN was forced to shut down its free-to-air stations in compliance with the cease-and-desist order issued on account of its expired franchise.

[17] On May 17, 2016, Tubig at Langis received the highest TV rating of 18.1% with its episode, "Sukdulan", versus its rival program The Millionaire's Wife which only registered 10%.

[20] On July 15, 2016, The series beat its all-time high rating and registered 18.5% with its episode, "Pahamak", compared to Sa Piling ni Nanay which is the rival program who only got 10.8%.

[21] On July 29, 2016, The series once again beat its all-time high ratings and registered 19.4% with its episode, "Pag-Amin", compared to Sa Piling ni Nanay who only got 10.4%.

[23] On August 8, 2016, Tubig at Langis beat its previous all-time high of 19.8%, and scored 20.1% with its episode, "Aresto", compared to its rival program, Sa Piling ni Nanay who only got a low rating of 9.7%.

[25] On September 2, 2016, more viewers tuned in to the finale of the series, which recorded its all-time high national TV rating of 21.6% compared to Sa Piling ni Nanay that only got 12.3%.