Kamulu was originally settled by the White settlers of Kenya who established plantations during the Colonial era.

Kamulu was later given to the Kenyan republic government and designated as a residential suburb in Nairobi.

Kamulu is found along the proposed dual carriageway of Kangundo Road roughly 35 kilometres (22 mi) east of Nairobi.

As you move toward interior Kamulu, roads are murram but are on schedule for upgrading to bitumen standards.

In Kamulu town,the largest densely populated area in the neighborhood, roads might be slightly impassable during the rainy season.

Kamulu was once connected to the Nairobi water and sewerage system but later disconnected for reasons which remain uncertain to the residents.

The boundary between Nairobi County and Machakos County lies at one end of the Kamulu area at the Athi River Bridge, making Kamulu the Eastern-most entry to Nairobi according to the District & Boundaries Act of 1992.

The Kamulu neighborhood remains ones of the most sought-after areas for real estate development in Kasarani Constituency.