[6] Panjabi became known for portraying negative roles in Indian television serials like Reth, Astitva...Ek Prem Kahani and Banoo Mein Teri Dulhann.

Panjabi has also played positive roles in Piya Ka Ghar, Maryada: Lekin Kab Tak and Kyun Hota Hai Pyaar.

[8] Panjabi featured in minor roles in Bollywood films such as Kaho Naa Pyaar Hai, Na Tum Jaano Na Hum, Yaadein, Phir Bhi Dil Hai Hindustani and Koi Mil Gaya and the Telugu film Maa Aavida Meeda Ottu Mee Aavida Chala Manchidi.

[citation needed] In 2019, Panjabi made her theatre debut in the play Pajama Party with fellow television actress Kavita Kaushik.

[1] During her time in Bigg Boss 7, Panjabi developed a close friendship with television actress Pratyusha Banerjee.