One of the highest-paid television actresses in India,[2][3] Khan is widely recognised for portraying Akshara Maheshwari Singhania in Yeh Rishta Kya Kehlata Hai (2009–2016).

[4] Post her work in Yeh Rishta Kya Kehlata Hai, Khan emerged as the runner-up in the eighth and the eleventh seasons of the reality shows Fear Factor: Khatron Ke Khiladi (2017) and Bigg Boss (2017–2018).

[9] Later, during her college studies in Delhi, Khan auditioned for Yeh Rishta Kya Kehlata Hai when her friends forced her and was selected for it.

[10] She moved to Mumbai and made her television debut in 2009, when she starred in one of the longest running Indian soap operas as Akshara Maheshwari Singhania.

[18] On 31 March, it was announced that she had signed in to make her digital debut with Ankoosh Bhatt's short film, 'SmartPhone', opposite actor Kunaal Roy Kapur.

[21][22][23][24] In the same year, she signed her debut film Lines, opposite actress Farida Jalal, which is directed by Hussain Khan and written by Rahat Kazmi and Shakti Singh.

[30] Khan played the main lead in a cameo appearance in the fifth season of Ekta Kapoor's Naagin along with Dheeraj Dhoopar and Mohit Malhotra.

[31] In February 2020, Khan made her Bollywood entry with the film Hacked, with director Vikram Bhatt, alongside Sid Makkar.

[43][44] Khan has established herself as one of the leading and highest-paid actresses of the Hindi television, with her acting performances in the series - Yeh Rishta Kya Kehlata Hai and Kasautii Zindagii Kay 2.

[54] In 2018, Khan became the victim of troll for posting the image of her teddy bear named Pooh, when saving her co-contestant Luv Tyagi during the task in Bigg Boss.

After that she appeared as a guest in Sapna Babul Ka... Bidaai, Saath Nibhaana Saathiya and Chand Chupa Badal Mein in 2010.

[67][68] For Yeh Rishta Kya Kehlata Hai, Khan has won two ITA Award for Best Actress - Popular, among three nominations.