Kanimozhi belongs to the Indian political party Dravida Munnetra Kazhagam (DMK), where she functions as the deputy general secretary.

[8] In 2007, Kanimozhi conceived the idea of the Chennai Sangamam, an annual open Tamil cultural festival, usually held during the Pongal season.

[citation needed] She spearheads[9] DMK efforts to organise job fairs, under the banner 'Kalaignar 85' across rural Tamil Nadu to facilitate employment opportunities for young people in smaller cities, towns and villages.

Kanimozhi has worked on a production titled Silappadikaram, A woman of Substance based on a Tamil epic of the same name with Bombay Jayashri.

[citation needed] CBI alleged that Kanimozhi was an "active brain" behind the channel's operations and she worked along with former telecom minister A. Raja to get DB Realty promoter Shahid Balwa to circuitously route 2 billion (US$36.2 million) to Kalaignar TV.

A. Kanimozhi had spent 190 days in Tihar Jail in 2011 after the CBI named her an "active brain" behind the functioning and setting up of Kalaignar TV.

[18] Raja was further pursuing the cause of Kalaignar TV not only for getting registration of the company from Ministry of Information and Broadcasting but also for getting it in the DTH operator TATA Sky's bouquet.

[citation needed] On 3 July 2012, briefing the joint parliamentary committee probing the scam, ED claimed that it has enough evidence to convict DMK chief Karunanidhi's wife and daughter Kanimozhi.

[19] During the course of the trial, Kanimozhi's name was cleared by at least one witness who deposed that she had no involvement in the day-to-day affairs of Kalaignar TV and that she was initially reluctant to join the management of the channel.