[1] It is written about a 20-year-old reporter, Ayesha Khan, living in one of the world's most beautiful cities, Karachi, about her misadventures and finding a nice lover.

Santana praised the author's complex and tenacious depiction of the protagonist, unlike Bridget Jones and traditional portrayals of Pakistani women.

[3] Somak Ghoshal wrote for the Mint that "the satire is pitch perfect and may hit those of us who live in the subcontinent harder than the rest" and that the "refreshingly devoid of glosses and translations, Imtiaz's novel is unapologetically faithful to the cultural nuances from which it emerges.

"[4] In the Hindustan Times review by Manjula Narayan was also positive, stating that "a comedy of manners, an incisive look at the journalistic life, an examination of a city with a dangerous edge, and an attempt to stand chicklit on its head, Karachi, You're Killing Me!

"[7] The Friday Times Mohsin Sidiqui praised the author and the novel, and stated that "Ms. Imtiaz has managed to pull together a novel that you want to read and share with people, not because of a misplaced sense of "Oh crap, it's another Pakistani writer, I suppose I have to be mildly positive," but instead because it's actually laugh-out-loud funny, witty, and entertaining.