[1] The club won the 2024 National Women Football Championship in their first participation in the country's top flight domestic circuit.

The club was formed in 2021 by football coach Adeel Rizki,[2] along with businessman and co-founder Shahzaib Ahmed Khan in Karachi.

[1][4] After the appointment of Adeel Rizki as coach of the Pakistan women's national team in 2022, most of the players of the club featured internationally.

[10] In their first match in the group stage, Karachi City achieved a historic victory by defeating Jahangir Memorial WFC with a score of 44–0.

The club represents Mazar-e-Quaid on their logo, one of the most popular monuments in Pakistan in honour of the country's founder Muhammad Ali Jinnah.