[1] Karachi Press Club is the place where regularly demonstrations, rallies and protests are organised against the government and for the demand of the civil and human rights by people and organizations.

[5][6][7] On 27 March 2016, the Karachi Press Club was attacked by protesters carrying pictures of Mumtaz Qadri, the murderer of Salman Taseer.

On the same day a massive crowd marched from Rawalpindi to Islamabad to protest his execution and the Karachi attackers retaliated for "lack of coverage of their event.

[9] On 8 November 2018, armed plainclothes security forces entered the club against its rules and made photos and videos inside, and a journalist was later arrested at his home and charged with possession of Islamic State materials.

[10] An exterior wall of the Club features a mural painted by artist Haider Ali that portrays notable Pakistani women including Yasmeen Lari, Pakistan's first female architect and Sabeen Mahmud, a prominent activist.