Karaginsky District (Russian: Караги́нский райо́н) is an administrative[1] and municipal[5] district (raion) of Koryak Okrug of Kamchatka Krai, Russia, one of the eleven in the krai.

It is located in the northern central part of the krai.

The area of the district is 40,641 square kilometers (15,692 sq mi).

[2] Its administrative center is the urban locality (a settlement) of Ossora.

[3] Ethnic composition (2021):[9] Karaginsky District is at one end of the world's longest estimated straight-line path over water (32,090 km, ending at the Sonmiani in the Balochistan province in Pakistan).