Penzhinsky District (Russian: Пе́нжинский райо́н) is an administrative[1] and municipal[4] district (raion) of Koryak Okrug in Kamchatka Krai, Russia, one of the eleven in the krai.

Its administrative center is the rural locality (a selo) of Kamenskoye.

[3] Ethnic composition (2021):[8] The area of the district is 116,086 square kilometers (44,821 sq mi).

[2] The Ichigem Range, the northwesternmost range of the Koryak Highlands, rises in the district.

Rivers Penzhina, Belaya, Oklan, Esgichninvayam and Zhirovaya are the main rivers flowing through the territory of the district.