Karanda Mission Hospital was established in 1961 to meet the needs of mission stations in the Zambezi River valley which were established as churches and then, as the abundant health care challenges were seen, small dispensaries/clinics were developed along with the churches (then came schools).

Karanda is in a remote area of northern Zimbabwe nearest to Mount Darwin.

Its location is approximately 200 kilometres (120 mi) from the capital, Harare.

The hospital is licensed for 150 beds and on an average work day sees between 10–20 surgeries and 200–300 outpatients.

The facility is known for the large number of surgical cases it handles as well as treating HIV/AIDS, tuberculosis, obstetrics, and hydrocephalus.