Karen B. Avraham (Hebrew: קרן אברהם) is an Israeli-American human geneticist and the first female Dean of the Tel Aviv University's Faculty of Medicine.

As a full professor at Tel Aviv University, and the current Dean of the Faculty of Medicine,[2] Avraham has a laboratory in the Department of Human Molecular Genetics and Biochemistry and holds the Drs Sarah and Felix Dumont Chair for Research of Hearing Disorders.

Her team studies the molecular basis of hearing loss using genetic, developmental, biochemical, cellular and bioinformatic tools.

She leads the effort in exome sequencing for the discovery of disease genes to identify mutations that are relevant for the hearing-impaired population.

Her group has demonstrated that microRNAs are essential for development and function of inner ear hair cells in vertebrates and has characterized the first long non-coding RNAs (lncRNAs) and methylation in the auditory system.