Berger majored in English literature and art history at Brooklyn College, and upon her graduation in 1979, she entered the comics profession as an assistant to editor Paul Levitz at DC.
More interested in horror comics, she soon became editor of House of Mystery,[1] and was instrumental in nurturing Alan Moore's Swamp Thing book, taking over the editing from co-creator Len Wein.
[2][3] The success of these titles, and her willingness to help the writers who worked with her push the envelope of what could be done in mass-circulation comic books, led to the creation of the mature-reader Vertigo line in 1993.
[5] On December 3, 2012, she announced that she would be stepping down from her post as Executive Editor & Senior Vice President of DC Entertainment's Vertigo imprint and that she would remain on through March 2013 to assist in the transition to a new editorial team.
[6] The New York Times profiled Berger and her departure from Vertigo in an article entitled "Comics' Mother of 'The Weird Stuff' is Moving On".