Karen began her career at Pyramid Broadcasting with six years at Kiss 108 WXKS-FM, Boston.
Blake was also heard on Country Format WKLB-FM owned by Fairbanks Communication's for three years hosting Afternoon Drive.
She then spent 9 years at Entercom, Boston – CHR/Rhythmic station Star 93.7 WQSX (now WEEI-FM) co-hosting Morning Drive.
In October 2005, Blake joined CBS Radio's Variety Hits station 103.3 WODS (Oldies 103) in Boston, hosting the Afternoon Drive position from 2:00 p.m. to 6:00 p.m.
In August 2012, Karen began working on-air at CBS station Mix 104.1 WBMX Boston.