Karen Elizabeth Keitley Duff (born 1965) is a British scientist known for her work on Alzheimer's disease.

Her most notable work focused on the development and characterization of mouse models of Alzheimer's disease amyloid deposition.

[1][2] She became Centre Director of the UK Dementia Research Institute's hub at University College London in spring 2020.

[3] She was educated at the University of East Anglia (BSc, 1987) and completed her PhD at Queens' College, Cambridge in 1991.

She was awarded the Potamkin Prize in 2006, together with Karen Ashe and Bradley Hyman.