Karen Helen Wiltshire (born 1962) is an Irish environmental scientist.

She is professor for shelf-ecosystems and was one of the vice directors of Alfred Wegener Institute for Polar and Marine Research (AWI).

She received her Ph.D. and habilitation (2001) in hydrobiology at the University of Hamburg.

She worked as a postdoctoral fellow at the GKSS Geesthacht [de], the University of St. Andrews, Scotland and was appointed Professor of Geosciences at Jacobs University in 2006.

[2] Wiltshire supports Scientists for Future in Germany and took part in a statement at the Bundespressekonferenz in March 2019.