Karen Elizabeth Hayden Miga is an American geneticist who co-leads the Telomere-to-Telomore (T2T) consortium that released fully complete assembly of the human genome in March 2022.

[2] In 2012, Miga joined the laboratory of David Haussler at the University of California, Santa Cruz.

[4] There she leads the telomere-to-telomere (T2T) consortium,[4][5] a community based effort that seeks to fully sequence and assemble the human genome.

[5] In 2022, Miga participated in the closing plenary session of the Clinton Global Initiative meeting,[8] where she discussed the future of equitable genomics research with former President Bill Clinton, U2 lead singer Bono, and Director-General of the World Health Organization (WHO) Tedros Ghebreyesus.

2023, Karen Miga was named a 2023 Searle Scholar[9] to study uncharted heterochromatin regions of the human genome.