Karen Sinclair (born 20 November 1952) is a Welsh Labour politician, who represented the constituency of Clwyd South from when the National Assembly for Wales was established in 1999, until she stood down, in 2011.

Born and brought up in Wrexham, north Wales, Sinclair has lived in Llangollen for over twenty years.

Sinclair has been a school governor at Ysgol Dinas Brân and chair of the Youth Club Committee.

She chairs the URBAN II West Wrexham regeneration project monitoring committee and is a member of UNISON.

Sinclair contested the Clwyd South constituency in the First National Assembly for Wales elections, and won the seat with a majority of 3,685 against Plaid Cymru's Hywel Williams.