She received her first film and television roles in the debut film Marla by Marta Malowanczyk, in which she played the leading role and which was nominated for the First Steps film award, as well as in Tatort: … es wird Trauer sein und Schmerz.

Since then, she has appeared in short, feature and television films.

Since 2016, she has portrayed Karin Gorniak as part of the investigative team of Winkler, Gorniak and Schnabel in the MDR contribution to the long-running television series Tatort ("Dresden Detectives" episodes).

[1] On 5 February 2021, as part of the #ActOut initiative in SZ-Magazin, Hanczewski came out as lesbian[2][3] alongside 184 other lesbian, gay, bisexual, queer, non-binary and transgender actors.

The initiative was initiated jointly by Godehard Giese, Eva Meckbach and Hanczewski herself in order to create further acceptance in their industry and in society.