Istomin started as a regular scrivener, then held the post of editor, and later became the head of the yard.
He is known to have authored and translated from Latin historical, religious, and pedagogical works, including his Arithmetics (Арифметика) and the Book of Reasoning (Книга вразумления), in which Istomin directed the 11-year-old Peter I on proper manners.
[2] Also, he wrote numerous acathistuses, prayers, epitaphs, and panegyrical, congratulatory, and edifying poems.
Istomin also wrote in verse the lives of the saints, an edifying treatise for schoolchildren called Домострой (Domostroy, or 'Household Management'), and a book named Полис ('Polis'), which was a short encyclopedia for younger readers, written in verse.
[2] Being an active supporter of the Petrine reforms in Moscow, Istomin was one of the first in Russia to realize the necessity of co-education of boys and girls.