He played in Major League Baseball (MLB) from 1946 to 1949 and 1951 to 1954 for the New York Yankees, St. Louis Browns, Philadelphia Phillies, and Cincinnati Redlegs.

A Staten Island, New York native, Drews appeared in two games for the Yankees in the 1947 World Series as a relief pitcher and held the Brooklyn Dodgers to one run and two hits in three innings pitched, although he did allow a base on balls and a hit batsman and threw a wild pitch.

During his MLB career, Drews appeared in 218 games played, 107 as a starting pitcher, and gave up 913 hits and 332 bases on balls in 8262⁄3 innings, with 322 strikeouts.

In his finest season, with the 1952 Phillies, he finished third in the National League (NL) in shutouts (five), sixth in complete games (15), and seventh in earned run average (ERA) (2.72).

[2] His grandson, Matt Drews, is a former Minor League Baseball (MiLB) right-handed pitcher selected by the Yankees in the first round of the June 1993 MLB Draft,[3] who played for seven seasons.